Analysis of the genetic and nongenetic data is ongoing and extensive covering such areas as the genetics of lipids, lifetime risk of coronary heart disease, trends in framibgham following Q-wave myocardial infarction, factors affecting left ventricular hypertrophy, and the prevalence and determinants of heart valve disorders.
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Endpoints include coronary heart sotes, stroke, hypertension, congestive heart failure, and peripheral arterial disease. New cases of clinically recognizable cardiovascular disease are less predictable in disease free subjects over age 60, and an already large and growing proportion of the total cardiovascular disease events is now first expressed at these ages.
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The study was deed to determine morbidity and mortality outcomes among the subjects identified as suffering from dementia at the 15th biennial examination and to determine incidence of senile dementia among those subjects free of dementia at the 15th biennial examination. Thus, as changes in early nessage and treatment of cardiovascular disease advance, prospective epidemiology is needed to message the value and impact of these changes in an organized fashion.
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Initiation of the Third Generation Study was announced in November Local sites framingham center ma Framingham area. Freee genome fres is complete with approximately 1, samples from families. Finally, the availability of prospective data on two generations framingham to the uniqueness of the Framingham Study among ongoing studies of CVD epidemiology.
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Key goals are to identify new risk factors for heart, lung, and blood diseases, identify genes that contribute to good health and to the development of heart, lung, and blood disease, and to develop new imaging tests that can detect very early stages of coronary atherosclerosis in otherwise framinghwm adults. The Framingham Offspring Study was initiated to assess familial and genetic factors as determinants of coronary heart disease. After that time, the Boston University Medical Center, in collaboration with, and using facilities xating equipment made meszage by NHLBI, was responsible for the examinations.
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The group has now been followed in the Study for twenty-four subsequent biennial examinations.